식품영양학과 BK21사업팀, 감염성질환제어연구센터(IDMRC) 및 식의약품의 효능평가 및 기능성소재개발센터(RIC)에서는 다음과 같이 공동세미나를 개최할 예정이오니 관심 있는 분들의 많은 참석 바랍니다.
- 다 음 –
▶ 일 시 : 2007년 10월 29일(월) 오후 4시~ ▶ 장 소 : RIC & IDMRC 공동세미나실 ((구) 도서관 3층 4317호) ▶ 연 자 : 이 용 우 교수(virginia tech wake forest university) ▶ 제 목 : Is Inflammation A Common Mechanism of Human Disease? ▶ 초 록 : Inflammation has been implicated in many human diseases including neurological disorders, cardiovascular diseases, and cancer. It is now generally accepted that enhanced expressions of pro-inflammatory cytokines, chemokines, and adhesion molecules facilitate recruiting and adhering of inflammatory cells, such as lymphocytes and monocytes/macrophages, into the vessel wall, and then stimulate transendothelial migration, which can be considered critical early pathologic events in these diseases. Our understanding of the cellular and molecular mechanisms involved in the inflammatory disease process, however, is currently limited. We have demonstrated that inflammatory responses elicited by various stimuli may play a critical role in the initiation and progression of inflammatory disease. Specifically, effects of a variety of risk factors, such as HIV, drug abuse, IL-4, fatty acids, environmental toxicants, and aging, on inflammation will be discussed in this presentation. Previous studies have indicated that brain irradiation can lead to functional cognitive impairments months to years after treatment. In deed, brain radiation therapy results in a progressive dementia in approximately 20-50% of brain tumor patients. At the present time, there are no known causes for radiation-induced brain injury, nor are there any successful treatments and effective preventive strategies. We hypothesize that the deleterious effects of radiation on the cerebrovasculature may be as part of the mechanism for the late effects of radiation-induced brain injury and subsequent neurological disorders. Our most recent in vivo data demonstrating effects of radiation on the pro-inflammatory and pro-angiogenic pathways in rat brain will be presented. These findings will provide novel insights into a complex inflammatory process of human disease and will have a high probability of revealing new directions that lead to basic and clinical research efforts on important public health problems for individuals with inflammatory diseases.